The V-100 small animal ventilator is a high-performance, high-precision ventilator independently developed and designed by Yuyan Instrument specifically for small experimental animals (mice, rats, guinea pigs, etc.). It has the characteristics of accurate control, convenient and practical use, and stable performance. Real time digital display of respiratory parameters (respiratory rate, respiratory ratio, tidal volume, airway pressure) for intuitive observation.

The V-100 small animal ventilator adopts constant volume and constant pressure control to ensure sufficient ventilation for animals. The range of tidal volume regulation is 0-10ml, and the range of respiratory rate regulation is 1-300 beats per minute. It is suitable for small animals that require small amounts of air, such as mice, rats, guinea pigs, hamsters, etc.

V-100 adopts constant volume positive pressure breathing, with a preset ventilation volume during operation. The ventilator stops delivering air after reaching the preset volume, relying on the elastic retraction force of the lungs and chest to passively exhale. Adopting a constant volume ventilation mode can ensure that the same volume of gas is introduced to the animal each time, meeting sufficient ventilation for the animal. Built in imported long-life air pump ensures stable and accurate gas flow output. The ventilator rhythmically outputs airflow according to the set parameters, enters the animal's lungs through the inhalation tube, and expands the lungs to achieve gas exchange. In the constant pressure control mode, by setting the airway pressure, the airflow can be easily adjusted, and the actual breathing parameters are displayed on the LCD screen. The pressure mode and capacity mode are switched through a switch. In any mode, automatic sighing can be achieved by setting the sighing function.

Main features of the product:

1. Suitable for small experimental animals such as rats, mice, guinea pigs, and rabbits;
2. Electric controlled ventilator, no need to use high-pressure air source;
3. Ventilation modes: intermittent positive pressure ventilation, continuous positive pressure ventilation, constant volume ventilation, constant pressure ventilation, automatic sigh ventilation;
4. Rat specific respiratory pathway, low dead space, stable tidal volume output;
5. Equipped with two types of endotracheal tubes for mice and rats, which can be inserted non invasively from the mouth for assisted breathing;
6. Change the set parameters at any time during the work process, which will take effect immediately without stopping the operation for setting;
7. Touch film button control, convenient and user-friendly to use;
8. Can be paired with a gas anesthesia machine to form an anesthesia respiratory system;
9. Range of respiratory rate regulation: 1-200 beats per minute;
10. The minimum tidal volume output is 100uL, with a step size of 100uL and an upper limit of no less than 10mL;
11. Digital display is intuitive and clear, with real-time display of parameters such as tidal volume, respiratory pressure, and inhalation/exhalation ratio;
12. Breathing ratio: 1:5-5:1, step 0.1, arbitrarily set, up to thousands of breathing ratios;

Model: V-100 (New)

Application areas:

Suitable for small experimental animals such as rats, mice, guinea pigs, and rabbits, it can be used for scientific research experiments in basic medicine, clinical medicine, and animal medicine (such as myocardial ischemia model production, lung function assessment), as well as respiratory management, animal emergency treatment, respiratory therapy, etc. in animal clinical procedures.

Configuration List:

model: V-1000

Main features:

·Multiple adjustable and controllable respiratory parameters: respiratory rate, ventilation volume, airway pressure, inspiratory ratio, pressure trigger threshold, sigh trigger threshold, etc;
·Equipped with a medical grade 5-inch IPS LCD screen, resolution: 720 * 1280;
·Equipped with sigh breathing function, adjustable range of sigh cycle: 0-999;
·Equipped with shuttle control knob: convenient for parameter adjustment during surgery;
·Equipped with inhalation light, exhalation light, and inhalation maintenance LED light, it can display instantaneous ventilation pressure and facilitate real-time monitoring of the operation status of the ventilator;
·Real time display of airway pressure waveform;
·Real time display of tidal volume linear graph;
·Equipped with USB data interface for remote control and triggering settings in conjunction with imaging system;

model: V-1000

·Three channel configuration: Three breathing channels can be independently controlled;

·Can perform assisted respiration on three rats and mice simultaneously;

Rat and mouse laryngoscopes

Tracheal intubation platform

CG-02M type, suitable for mice, outer dimensions: 20 * 15 * 20cm

CG-02R type, suitable for rats, outer dimensions: 22 * 21 * 28cm

CG-04M model, mouse specific style

Animal tracheal intubation

Outer diameter 0.5mm, packaged in 5 pieces, for mice

Outer diameter 0.75mm, packaged in 5 pieces, for mice

Outer diameter 1.0mm, 5 packages, for mice

Outer diameter 1.5mm, packaged in 5 pieces, for small rats

2.5mm outer diameter, packaged in 5 pieces, used for rats or guinea pigs

3.0mm outer diameter, 5 packages, for rats or guinea pigs

reference:

1.Sun, Zhenxing et al. “Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction.” Theranostics vol. 10,11 4967-4982. 6 Apr. 2020, doi:10.7150/thno.43233
2.Zhang, Li et al. “Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction.” Theranostics vol. 7,1 51-66. 1 Jan. 2017, doi:10.7150/thno.16074
3.Cai, Heng et al. “Mild Hypothermia Promotes Ischemic Tolerance and Survival of Neural Stem Cell Grafts by Enhancing Global SUMOylation.” Oxidative medicine and cellular longevity vol. 2022 6503504. 27 May. 2022, doi:10.1155/2022/6503504
4.Zhang, Xuerui et al. “Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells.” Frontiers in immunology vol. 9 2038. 10 Sep. 2018, doi:10.3389/fimmu.2018.02038
5.Ma, HaiXiang et al. “Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest.” iScience vol. 25,10 105228. 27 Sep. 2022, doi:10.1016/j.isci.2022.105228
6.Ren, Wenbo et al. “Moderate hypothermia induces protein SUMOylation in bone marrow stromal cells and enhances their tolerance to hypoxia.” Molecular medicine reports vol. 16,5 (2017): 7006-7012. doi:10.3892/mmr.2017.7425
7.Zhang, X-G et al. “Investigating the expression of miRNA-133 in animal models of myocardial infarction and its effect on cardiac function.” European review for medical and pharmacological sciences vol. 23,13 (2019): 5934-5940. doi:10.26355/eurrev_201907_18338
8.Wang, Juntao et al. “Protective effects of dexmedetomidine on lung in rats with one-lung ventilation.” Experimental and therapeutic medicine vol. 17,1 (2019): 187-192. doi:10.3892/etm.2018.6952
9.Qing, Hua et al. “Regulation of adventitial interstitial fluid circulation by heartbeat and respiration.” bioRxiv doi:10.1101/2022.10.18.512678
10. Han Yue, Diao Yugang, Song Dandan, etc Improvement of the model of cardiac arrest during extracorporeal circulation in bloodless pre filled rats [J]. Chinese Journal of Extracorporeal Circulation, two thousand and twenty

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